Search Site

Research

The Division of Stroke and Cerebrovascular Disease in the Department of Neurology at NewYork-Presbyterian/Columbia University Medical Center has been pursuing cutting edge clinical research for nearly 30 years. Faculty within our division conduct NIH- and foundation-sponsored research in all facets of stroke and cerebrovascular disease. Our investigators currently run a number of stroke clinical trials, including the investigation of high dose statins for neuroprotection in acute stroke, an international study of surgery versus medical management of unruptured brain arteriovenous malformations, and the use of educational interventions in the Emergency Department to reduce the rates of stroke recurrence.  In the area of stroke recovery we are testing novel pharmaceutical agents and robotics to improve stroke motor deficits. Other investigators have initiated novel community education efforts working with school-age children to recognize signs of stroke in their family members, and another new project using arterial specimens and advanced imaging techniques to investigate the pathophysiology of arterial disease. Our group is also involved in national, multi-center trials of intra-arterial stents and brain cooling for acute stroke, and the use of surgery versus stenting versus medical therapy for asymptomatic carotid artery disease.

Our faculty have led the country in population and community-based research, as well. The Northern Manhattan Study, a landmark epidemiological effort, was established in 1990, and has contributed to groundbreaking knowledge of stroke risk in minority populations. This study and other Columbia epidemiological studies of stroke risk factors in children and adults have continued to move the field forward in the investigation of novel stroke risk factors and stroke genetics. Our community-based research has also resulted in a highly effective stroke prevention program targeting school-age children in underserved populations who are learning to recognize and act on stroke signs in their relatives and neighbors, thus helping to reduce the burden of stroke in those communities.

In the laboratory, our division is investigating the underlying mechanisms of blood flow in the brain and the pathophysiology of vascular remodeling that contributes to stroke risk. Our investigators use advanced imaging methods, cerebral ultrasound, and neuropathological techniques to understand how the brain reorganizes after injury, and how brain arteries remodel in response to atherosclerotic stress factors.

To learn more about our laboratory investigations and overall research in our division, please visit the research section of this website.