Search Site

Estela Area Gomez, PhD

  • Assistant Professor in the Department of Neurology
Estela Area Gomez, PhD

I received my Ph.D. from the University of University Autonoma of Madrid (Spain), after which I transitioned into the field of mitochondrial research and neurodegeneration as a post-doctoral research scientist at the Merritt Center in the Neurology Department at Columbia University. In 2014, I joined the faculty of the Neurology department at Columbia University as an Assistant Professor. My laboratory has three major research goals: (i) To understand the role of mitochondria-associated ER membranes (MAM) in the overall lipid homeostasis in neurons; (ii) To understand whether perturbations in mitochondria-associated ER membranes (MAM) and lipid signaling underlie synaptic dysfunction, and/or neuronal death in various disorders, including Alzheimer's disease and Amyotrophic Lateral Sclerosis; and (iii) To identify lipid biomarkers that either segregate with or predict clinical outcome of neurological disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Down syndrome. To tackle these fundamental questions, my lab employs multidisciplinary approaches, which range from molecular and cell biology, protein and lipid biochemistry (including state-of-the-art ‘lipidomics’-based approaches) to mouse genetics and behavioral assessments of genetically-modified mice.

Departmental Appointments

  • Department of Neurology
    Division of Neuromuscular Medicine

NIH Grants

  • ROLE OF C99 IN THE REGULATION OF LIPID METABOLISM- RELEVANCE TO ALZHEIMER S DISEASE (Federal Gov)

    Aug 1 2017 - May 31 2022

    ENDOPLASMIC RETICULUM MITOCHONDRIAL MEMBRANES IN ALZHEIMER S DISEASE (Federal Gov)

    Sep 1 2014 - Jun 30 2019

    APPROACHES TO DIAGNOSIS AND TREATMENT OF ALZHEIMER DISEASE (Private)

    Jun 1 2017 - May 31 2018

    A NEW VIEW OF MITOCHONDRIAL DYSFUNCTION IN ALS (Private)

    Apr 1 2016 - Mar 31 2017

    TREATMENT STRATEGIES FOR HUMAN MITOCHONDRIAL DISEASE (Private)

    Feb 1 2013 - Jan 31 2016

    TREATMENT STRATEGIES FOR HUMAN MITOCHONDRIAL DISEASE (Private)

    Nov 1 2012 - Oct 31 2015

    INCREASED ER-MITOCHONDRIAL COMMUNICATION IN THE PATHOGENESIS OF ALZHEIMER DISEASE (Federal Gov)

    Jul 1 2012 - Feb 28 2015

    MITOCHONDRIA-ASSOCIATED MEMBRANES IN ALZHEIMER DISEASE (Private)

    Nov 1 2009 - Nov 2 2014