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Hiroshi Mitsumoto, MD

  • Wesley J. Howe Professor of Neurology at CUMC
  • Director, ALS/PLS (Amyotrophic/Primary Lateral Sclerosis) Center
  • Director, MDA/ALS Clinic
Hiroshi Mitsumoto, MD

Dr. Hiroshi Mitsumoto is the Wesley J. Howe Professor of Neurology at Columbia University at The Neurological Institute of New York and NewYork-Presbyterian Hospital/Columbia University Medical Center. Previously he was on the faculty of the Cleveland Clinic Foundation where he served as Director of the ALS Center. A graduate of Toho University School of Medicine in Japan, he completed his internship at Baltimore City Hospital at Johns Hopkins, residency training in Neurology at Case Western Reserve, as well as a neuromuscular fellowship training at Tufts New England Medical Center.

Dr. Mitsumoto has devoted his clinical and research effort to the investigation of ALS in both animal models and clinical trials in patients with ALS. He is presently conducting an NIH study of Disease Markers in ALS. Dr. Mitsumoto has published and lectured, nationally and internationally extensively on the topic of ALS. He served as a member of Steering Committee of several clinical trials in ALS.

He received the Donald C. Mulder Award for achievement, leadership, and dedication in ALS from ALS Association in 1996, in 1998 he became the 5th recipient of the Forbes Norris Award from the International Alliance of ALS/MND Associations for his "compassion and love of humanity in the study, management or support of ALS/MND, and in 2000 he received the Lou Gehrig Memorial Award from the MDA. He served as Chair of the ALSA Medical Advisory Board until 1999 and now is a member of the MDA Medical Advisory Board, ALS CARE Board of Directors, and Neurology editorial board.

Dr. Mitsumoto is presently conducting an NIH study of Disease Markers in ALS. Dr. Mitsumoto has published and extensively lectured, nationally and internationally, on the topic of ALS. He served as a member of Steering Committee of several clinical trials in ALS.

Departmental Appointments

  • Department of Neurology
    Division of Neuromuscular Medicine

Languages Spoken

(in addition to English)

  • Japanese

Education & Training

  • Tohoku University Medical School
  • Residency: Cleveland Clinic - Cleveland, OH
  • Fellowship: Cleveland Clinic - Cleveland, OH
  • Fellowship: Tufts University Hospital

Centers/Institutes/Programs

  • ALS/PLS (Amyotrophic/PRIMARY Lateral Sclerosis) Center

Committees/Societies/Memberships

  • Chair of the ALSA Medical Advisory Board
  • MDA Medical Advisory Board Present
  • ALS CARE Board of Directors Present
  • "Neurology" editorial board Present

Honors & Awards

  • Donald C. Mulder Award
  • Forbes Norris Award 
  • Lou Gehrig Memorial Award 

NIH Grants

  • CASE-CONTROL STUDIES NESTED IN NATIONAL ALS REGISTRY TO EVALUATE ENVIRONMENTAL RISKS (Federal Gov)

    Sep 30 2015 - Sep 29 2018

    GM604 PHASE 2A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED PILOT TRIAL IN AMYOTROPHIC LATERAL SCLEROSIS DISEASE (ALS) (P&S Industry Clinical Trial)

    Jul 25 2013 - Jul 25 2018

    A PROSPECTIVE COMPREHENSIVE EPIDEMIOLOGIC STUDY IN A LARGE COHORT IN THE NATIONAL ALS REGISTRY: IDENTIFYING ALS RISK FACTORS (Federal Gov)

    Sep 1 2013 - Aug 31 2017

    PHASE 2 STUDY OF RASAGILINE FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (Federal Gov)

    Sep 1 2013 - Aug 31 2017

    PHASE 2 STUDY OF RASAGILINE FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (Federal Gov)

    Sep 1 2013 - Aug 31 2017

    2015 WINGS OVER WALL STREET RESEARCH PROJECTS PROPOSAL (Private)

    Jan 1 2016 - Dec 31 2016

    AMERICAN-EUROPEAN JOINT MEETING FOR ALS CLINICAL TRIAL GUIDELINES 2016 (Private)

    Jan 1 2016 - Dec 31 2016

    AMERICAN-EUROPEAN JOINT MEETING FOR ALS CLINICAL TRIAL GUIDELINES 2016 (Private)

    Jan 1 2015 - Dec 31 2016

    ALS CLINICAL TRIALS GUIDELINES (Federal Gov)

    Sep 15 2015 - Sep 14 2016

    CY4024-CK2017357 (P&S Industry Clinical Trial)

    Jul 15 2011 - Jul 15 2016

    ALS CLINICAL TRIALS GUIDELINES (Private)

    Jul 1 2015 - Jun 30 2016

    ALS CLINICAL TRIAL GUIDELINES 2016 MITSUMOTO CLINICAL TRIAL CONFERENCE (Private)

    Jun 1 2015 - May 31 2016

    INTERNATIONAL CONFERENCE TO RENEW AND UPDATE THE ALS CLINICAL TRIAL GUIDLEIINES (Private)

    Jun 1 2015 - May 31 2016

    223AS302 -BIB050 (P&S Industry Clinical Trial)

    May 5 2011 - May 5 2016

    MULTICENTER ALS COHORT STUDY OF OXIDATIVE STRESS AND DISEASE PROGRESSION (Federal Gov)

    Jul 22 2009 - Apr 30 2016

    NEURALTUS (P&S Industry Clinical Trial)

    Apr 28 2011 - Apr 28 2016

    2014 MDA WINGS OVER WALL STREET RESEARCH PROJECTS PROPOSAL (Private)

    Sep 1 2014 - Aug 31 2015

    BIOCHEMICAL AND MOLECULAR CHARACTERISTICS OF PRIMARY LATERAL SCLEROSIS (Private)

    May 1 2013 - May 1 2015

    NEUROMUSCULAR DISEASE REGISTRY (Private)

    Aug 1 2014 - Dec 31 2014

    INFRASTRUCTURE OF A SMALL SCREENING TRIAL CONSORTIUM - MDA ALS CLINICAL RESEARCH NETWORK (Private)

    Jan 1 2012 - Dec 31 2014

    2013 MDA WINGS OVER WALL STREET RESEARCH PROJECTS PROPOSAL (Private)

    Sep 1 2013 - Aug 31 2014

    AN OPEN-LABEL SAFETY AND TOLERABILITY STUDY EVALUATING KNS 760704 IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS) (P&S Industry Clinical Trial)

    Aug 17 2009 - Aug 17 2014

    MULTICENTER PROSPECTIVE PLS NATURAL HISTORY STUDY (Private)

    Sep 1 2009 - Mar 31 2014

    OXIDATIVE STRESS AND RESPIRATORY FAILURE IN ALS: A PRELIMINA RY STUDY (WOW 11-12) (Private)

    Sep 1 2011 - Aug 31 2013

    2012 MDA WINGS OVER WALL STREET RESEARCH PROJECTS PROPOSAL (Private)

    Aug 1 2012 - Jul 31 2013

    CLINICAL TRIAL OF CEFTRIAXONE IN SUBJECTS WITH AMYOTROPHIC LATERAL SCLEROSIS (Federal Gov)

    Dec 1 2008 - Jun 30 2013

    WINGS OVER WALL STREET - ALS RESEARCH CENTER AT CUMC (Private)

    Jul 1 2006 - Jan 31 2013

    CLINICALLY MEANINGFUL CHANGES (CMC) SCALE IN THE MDA/ALS CLINICAL NETWORK (Private)

    Jul 1 2009 - Dec 31 2012

    TRIAL OF HIGH FAT/HIGH CALORIE DIET VERSUS OPTIMAL NUTRITION IN AMUOTROPHIC LATERAL SCLEROSIS (Private)

    Jul 1 2009 - Jun 30 2012

    NIH ALS CONFERENCE: CLINICAL RESEARCH TO FIND THE PATHOGENES IS AND CAUSE OF ALS (Federal Gov)

    Apr 1 2011 - Mar 31 2012

    WINGS OVER WALL STREET 2010-2011 (Private)

    Nov 1 2010 - Mar 31 2012

    INTERNATIONAL ALS CONFERENCE: TO PROMOTE CLINICAL RESEARCH T O FIND THE PATHOGENESIS AND CAUSE OF ALS (Private)

    Mar 1 2011 - Feb 29 2012

    DICHLORPHENAMIDE VS ACETAZOLAMIDE FOR PERIODIC PARALYSIS (Federal Gov)

    Dec 1 2006 - Nov 30 2011

    TALAMPANEL IN ALS (P&S Industry Clinical Trial)

    Sep 25 2008 - Sep 1 2011

    MDA CLINICAL RESEARCH NETWORK (Private)

    Aug 1 2008 - Jul 31 2011

    2008 WINGS OVER WALL STREET (Private)

    Jul 1 2009 - Jun 30 2011

    SKIN BIOPSIES FOR THE GENERATION OF ALS-SPECIFIC HUMAN EMBRY ONIC CELLS (Private)

    Feb 1 2007 - Jan 31 2011

    AVANIR -- 07 AVR 123 (P&S Industry Clinical Trial)

    Mar 27 2008 - Oct 31 2009