Jennifer Gelinas, MD, PhD
- Assistant Professor of Neurology (in the IGM and GH Sergievsky Center)
Jennifer Gelinas, MD, PhD is an assistant professor of neurology (in the Institute for Genomic Medicine and the Gertrude H. Sergievsky Center) at Columbia University Medical Center. Dr. Gelinas obtained her medical doctorate and doctorate degrees at the University of Alberta, Canada. She subsequently completed pediatric neurology residency at the University of British Columbia, followed by an epilepsy fellowship at New York University Langone Medical Center. Dr. Gelinas' clinical practice focuses on infantile and childhood epilepsy, with a special interest in epilepsy surgery and intracranial electroencephalography (iEEG).
In her doctoral research, Dr. Gelinas studied cellular mechanisms of learning and memory in the hippocampus. Her postdoctoral fellowship was with Dr. Gyorgy Buzsaki at New York University Langone Medical Center, investigating the effects of epileptic activity on neural networks involved in cognition, as well as advanced neural interface devices for the diagnosis and treatment of epilepsy. In her current research, Dr. Gelinas is focused on understanding how epileptic activity disrupts the proper development and function of neural networks. In vivo neurophysiology with advanced neural interface devices, behavioral memory tasks, responsive stimulation of neural networks, and neurocomputational methods are among the techniques used in her laboratory to investigate neural network dysfunction in epilepsy. The overall goal of her research is to identify novel biomarkers and systems level treatments for epileptic disorders, especially those affecting neonates and children.
- Department of Neurology
Division of Child Neurology
Education & Training
- MD, University of Alberta Faculty of Medicine (Canada)
- PhD, University of Alberta (Canada)
- Residency: British Columbia Children's Hospital, Canada
- Fellowship: New York University Langone Medical Center, Neuroscience Institute
- Fellowship: New York University Langone Medical Center
Science mentor for Independent Science Program (high school level), 2015-2016
NYU Neuroscience Outreach Organizer and Volunteer, 2014-2015
Science Mentor for i2 Science Challenge Program, 2013-2014
Laboratory Coordinator for CRISP (Clinically Rich Integrated Science Program), 2013-2014
Resident Lecturer at Neurology Academic Half-Day, University of British Columbia, 2011-2013
Neurology Resident Advisor for Pediatric Clerkship e-Health Initiative, University of British Columbia, 2010-2011
Teaching Assistant for Pediatrics Resident Half-Day, University of British Columbia, 2010-2011
Honors & Awards
Laura MacRae Award, Department of Pediatrics, BC Children’s Hospital, Award for Excellence in Pediatric Medicine, 2013
- Gelinas JN, Khodagholy D, Thesen T, Devinsky O, Buzsaki G (2016) Interictal epileptiform discharges induced hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med 22: 641–648.
- Khodagholy D*, Gelinas JN*, Zhao Z*, Yeh M, Long M, Greenlee JD, Doyle W, Devinsky O, Buzsáki G (2016) Organic electronics for high-resolution electrocorticography of the human brain. Science Advances 09 Nov 2016: DOI: 10.1126/sciadv.1601027
- Watson BO, Levenstein D, Greene JP, Gelinas JN, Buzsáki G (2016) Network homeostasis and state dynamics of neocortical sleep. Neuron Apr 27. pii: S0896-6273(16)30056-3. doi: 10.1016/j.neuron.2016.03.036.
- Krook-Magnusson E*, Gelinas JN*, Soltesz I, Buzsaki G (2015) Neuroelectronics and biooptics: closed-loop technologies in neurological disorders. JAMA Neurol 72:823-9.
- Khodagholy D, Gelinas JN, Thesen T, Doyle W, Devinsky O, Malliaras G, Buzsaki G (2015) NeuroGrid: recording action potentials from the surface of the brain. Nat Neurosci 18:310-5.
- Liao P*, Gelinas JN*, Sirrs S (2014) Phenotypic variability of Krabbe disease across the lifespan. Can J Neurol Sci 41:5-12.
- Gelinas JN, Fitzpatrick KP, Kim HC, Bjornson BH (2014) Cerebellar language mapping and cerebral language dominance in pediatric epilepsy surgery patients. Neuroimage: Clinical 6:296-306.
- Gelinas JN*, Liao P*, Lehman A, Stockler S, Sirrs S (2012). Krabbe disease – a potentially treatable white matter disorder. Neurology 79:e170-2.
- Gelinas JN, Battison A, Smith S, Connolly MC, Steinbok P (2011). Electrocorticography and seizure outcomes in children with lesional epilepsy. Childs Nerv Syst 27:381-90.
- O’Dell TJ, Connor SA, Gelinas JN, Nguyen PV (2010). Viagra for your synapses: Enhancement of long-term potentiation by activation of beta-adrenergic receptors. Cell Signal 22: 728-36.
- Gelinas JN, Tenorio G, Lemon N, Abel T, Nguyen PV (2008). Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus. Learn Mem 15: 281-9.
- Gelinas JN, Banko JL, Peters MM, Klann E, Weeber EJ, Nguyen PV (2008). Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learn Mem 15: 403-11.
- Gelinas JN, Banko JL, Hou L, Sonenberg N, Weeber EJ, Klann E, Nguyen PV (2007) ERK and mTOR signalling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent LTP. J Biol Chem 282: 27527-35.
- Gelinas JN and Nguyen PV (2007) Neuromodulation of hippocampal synaptic plasticity, learning, and memory by noradrenaline. Central Nervous System Agents in Medicinal Chemistry 7:1-17.
- Gelinas JN and Nguyen PV (2005) -adrenergic receptor activation facilitates induction of a protein synthesis-dependent late phase of long-term potentiation. J Neurosci 25:3294-3303.
*these authors contributed equally