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James M. Noble, MD, MS

  • Assistant Professor of Neurology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) at CUMC
  • Director, Neurology Clerkship
  • Director, Concussion and Sports-Related Head Injury Program
James M. Noble, MD, MS

Dr. Noble completed his undergraduate studies in math and chemistry at Vanderbilt University, followed by medical school at Emory University. His graduate medical training included internal medicine internship, neurology residency including chief resident in neurology, and neuroepidemiology and behavioral neurology fellowship, all at Columbia University Medical Center. Accordingly, he is board certified in neurology, behavioral neurology & neuropsychiatry, and public health.

Dr. Noble primarily sees patients with dementia but also leads Team Concussion, focusing on sports-related concussion care, and sees patients in a general neurology practice. Dr. Noble is fluent in Spanish and his comprehensive approach to care views the patient within the entire family dynamic, with particular focus on disadvantaged communities.

His professional leadership has been recognized by the American Academy of Neurology, which has selected him to the Emerging Leaders Forum. Dr. Noble is recognized as a leader in neurologic education at Columbia University College of Physicians and Surgeons, as its clerkship director and a scholar in the Virginia Apgar Teaching Academy. Dr. Noble is also the president of Arts & Minds, a non-profit organization promoting well-being for dementia patients and their caregivers via art-centered experiences.

In addition to patient care, Dr. Noble’s research interests include health literacy, systemic inflammatory markers as contributors to stroke and dementia health disparities, the role of cognitively stimulating activities in dementia care, and sports-related concussion.

Departmental Appointments

  • Department of Neurology
    Division of Aging and Dementia

Languages Spoken

(in addition to English)

  • Spanish

Education & Training

  • Emory University School of Medicine
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Centers/Institutes/Programs

  • Concussion and Sports-Related Head Injury Program
  • Gertrude H. Sergievsky Center
  • Taub Institute for Research on Alzheimer's Disease and the Aging Brain

Past Positions

Assistant Attending Neurologist
Harlem Hospital Center
July 2008 - June 2011

Presentations

Platform/Oral Presentations

  • Williams O, Noble JM, Brust JCM. Stroke associated with cocaine abuse: no longer just a problem of the young. Presented (by JMN) at the American Academy of Neurology Annual Meeting, April 6, 2006 S54.005, part of S54: Uncommon Causes of Stroke.
  • *Williams O, Noble JM. “Hip-Hop” Stroke Education in Central Harlem Elementary Schools: Pilot Data from a Novel Intervention and Proposed Educational Model for Stroke Awareness Developed by the National Stroke Association (presented by OW for Prevention Strategies at the 2007 International Stroke Conference, February 7, 2007)
  • *Noble JM, Manly JJ, Schupf N, Mayeux R, Luchsinger JA. Possible disparate contribution of diabetes to cognitive impairment in elderly minorities. (presented by JMN to the World Federation of Neurology North American Regional Meeting Conference, Boston, MA, May 4, 2007)
  • *Noble JM. The Relationship between Stroke and Dementia: Is this a Bigger Problem among Blacks and Hispanics? 3rd Annual Treatment and Prevention of Stroke in Black and Hispanic Populations. Harlem Hospital Center, New York, NY. Director: Olajide Williams MD MS. Sponsor: Columbia University College of Physicians and Surgeons. November 20, 2009.
  • *Noble JM. “Strategies to Decrease Cerebrovascular Risk in Harlem” as part of the “Community based multidisciplinary interventions to prevent and treat Cognitive Impairment and its Co-morbidities”, Columbia University Medical Center (CUMC), January 28th and 29th, 2010, sponsored by by the Columbia Center for the Health of Urban Minorities (CHUM) and by the Irving Institute for Clinical Translational Research (IICTR); PI: Jose Luchsinger MD MPH
  • *Noble JM. Periodontitis and cognitive impairment: implications of markers of systemic inflammation. Grand Rounds, Department of Medicine, Mountainside Medical Center, Montclair, NJ. 5/6/2010
  • *Noble JM. Periodontitis: a potential risk for cognitive decline? Greater New York Dental Meeting. New York, NY 11/28/2010
  • *Gonzalez-Castellon M, Phillips M, Blum C, Goldberg M, Noble JM. Assessing the Efficiency of Learning the Neurologic Exam with a Visual Tracking Device Presented (by MGC) at the American Academy of Neurology Annual Meeting, March 20, 2013, S27.007, part of S27: Neurologic Education.
  • *Noble JM, Hedmann MG, Williams O. Teaching Children about Dementia: Pilot Findings from the Hip Hop Old S.C.H.O.O.L. (Seniors Can Have Optimal aging and Ongoing Longevity) Program. Presented by JMN at Alzheimer’s Association International Conference, Boston MA, July 15, 2013, as part of “Public Health and Psychosocial: Education, Training and Technological Applications”

Poster Presentations

  • September 2005 American Neurological Association 130th Annual Meeting, San Diego CA. *Noble JM, Williams O, Brust JCM. “Recombinant tissue plasminogen activator (rtPA) for acute ischemic stroke amongst African-Americans in Central Harlem.” (P240)
  • May 2007 59th American Academy of Neurology Annual Meeting 2007, Boston MA. *Noble JM, Scarmeas N, Honig L. “Challenges in dementia diagnosis in a multiethnic population.” (P05.086)
  • February 2008 International Stroke Conference, New Orleans LA. Williams O, Wowo B, Noble J, Brust J. “Insurance Coverage And Ambulance Use During Acute Stroke In A Low Income Inner City Population.” (P231)
  • April 2008 60th American Academy of Neurology Annual Meeting Chicago, IL. *Noble J, Borrell LN, Papapanou PN, Elkind M, Scarmeas N, Wright C. “Association of the Periodontitis Pathogen Porphyromonas gingivalis with Poor Memory: Analysis of the Third National Health and Nutrition Examination Survey (NHANES-III)” [abstract]. (P04.079)
  • April 2009 61st American Academy of Neurology Annual Meeting Seattle, WA *Noble J, Schupf N, Luchsinger J. “Relation of high sensitivity C-reactive protein with plasma amyloid beta”
  • July 2009. Alzheimer’s Association International Conference on Alzheimer Disease, Vienna. *Noble JM, Manly JJ, Schupf N, Tang MX, Mayeux R, Luchsinger JA. Relation of C-Reactive protein to cognitive impairment.
  • September 2010. 135th Meeting of the American Neurological Association, San Francisco. *Williams O, DeSorbo A, Noble JM. “Lifetime Acquired Stroke Knowledge in a High Risk Community: Parents Versus Children. (Abstract #119, Poster M-33)
  • October 2010. 7th World Stroke Congress, Seoul, South Korea. *Williams O, DeSorbo A, Noble JM. “Child Mediated Intervention To Increase Public Stroke Knowledge: Findings from the Hip Hop Stroke Program.“
  • March 2011. Annual Meeting of the American Psychosomatic Society. San Antonio, TX. Williams OA, Gerin W, DeSorbo AL, Noble JM. “A Novel Interventional Strategy to Improve Stroke Awareness: The Hip Hop Stroke Project.” (Abstract #775)
  • February 2012 International Stroke Conference, New Orleans LA. Williams O, DeSorbo A, Noble J. Hip Hop Stroke: Long-Term Retention of Stroke Knowledge Among Sixth Graders Living in a Low-Income Neighborhood. (Abstract #2476, Community/Risk Factors I)
  • February 2012 International Stroke Conference, New Orleans LA. Williams O, DeSorbo A, Noble J. Hip Hop Stroke: The Standalone Effect of Musical Cartoons on Stroke Knowledge of Fourth Grade Children Living in a Low-Income Neighborhood (Abstract #2478, Preventive Strategies II)
  • July 16, 2012 Alzheimer’s Association International Conference, Vancouver, BC. Noble JM, Kang MS, Honig LS. Arteriosclerosis and Alzheimer disease: A case-control pathologic study. Abstract P2-102
  • July 17, 2012 Alzheimer’s Association International Conference, Vancouver, BC. Noble JM, Scarmeas N, Celenti R, Elkind MSV, Wright CB, Schupf N, Papapanou PN. Serum antibodies to periodontal pathogens are associated with incident Alzheimer Disease. Abstract P3-131
  • July 17, 2012 Alzheimer’s Association International Conference, Vancouver, BC. Collins-Praino L, Scarmeas N, Manly J, Schupf N, Noble J, Provenzano F, Griffith E, DeCarli C, Mayeux R, Luchsinger J, Brickman A. White Matter Hyperintensities May Mediate the Relationship Between Inflammation and Cognition in an Elderly Cohort. Abstract P3-193
  • March 19, 2013 American Academy of Neurology Annual Meeting, San Diego, CA. Wright B, Lewis L, Noble J, Vonsattel JP, Khandji A, Sommerville R, Wright C. Case Series: Eosinophilic Vasculitis Isolated to the Central Nervous System (P02.053) Neurology February 14, 2013 80: P02.053
  • October 2013 American Neurological Association Annual Meeting, New Orleans, LA. *Shams T, Brickman A, Gossett J, Levine W, Noble J. Subtle post-concussion cognitive  impairment is common, under-recognized, and yet identifiable: Findings from The Concussion in Columbia University Sports Student  (ConCUSS) Study.

Conferences/Symposia

  • Co-Chair: Community based multidisciplinary interventions to prevent and treat Cognitive Impairment and its Co-morbidities”, Columbia University Medical Center (CUMC), January 28th and 29th, 2010, sponsored by by the Columbia Center for the Health of Urban Minorities (CHUM) and by the Irving Institute for Clinical Translational Research (IICTR); PI: Jose Luchsinger MD MPH January 2010: Strategies to decrease Cerebrovascular risk in Harlem
  • September 16, 2013—October 21, 2013. Co-Chair: “Sackler Brain Bench: Neuroscience of Sports: Your Brain in Action” at the American Museum of Natural History, New York, NY.

Other Presentations:

  • *Noble JM and Williams O. Hip-Hop Stroke: Stumbling Before Success. 36th Annual Meeting of the New York State Society of Aging, Saratoga Springs NY, October 24, 2008
  • *Noble JM and Williams O. Hip-Hop Stroke: Empowering an Inner City Community to Identify and Prevent Stroke in the Elderly. Aging Concerns Unite Us Conference, New York State Association of Area Agencies on Aging, Albany NY, June 3, 2009

Community Service

  • President, Arts & Minds, Inc.

    Arts & Minds, Inc. is  a non-profit organization promoting well-being for dementia patients and their caregivers via art-centered experiences in Harlem.

Teaching Responsibilities

  • 2009 to present: Neurology Clerkship Director, Columbia University College of Physicians and Surgeons
  • 2009-present: Lecturer, Neuroepidemiology, Mailman School of Public Health

Honors & Awards

  • 2012 Selection, Emerging Leaders Forum, American Academy of Neurology 
  • 2012 Virginia Apgar Teaching Academy Scholar, Columbia University College of Physicians and Surgeons
  • 2011 Stephen Q. Shafer Award for Humanism in Neurology, Columbia University Medical Center 
  • 2008 Anna C. Gelman Award for Excellence in Epidemiology, Mailman School of Public Health, Columbia University  

Research Interests

  • Health literacy
  • Alzheimer disease
  • Chronic traumatic encephalopathy
  • Dementia
  • Lewy Body Disease
  • Frontotemporal dementia
  • Vascular dementia
  • Post-concussion syndrome

Grants

NIA T35 AG044303-01: The BRAIN (Brief Research in Aging and Interdisciplinary Neurosciences) Project, as co-Principal Investigator

NIH-NIDCR R56 DE022568-01A1 Periodontal Exposure and Risk of Incident Dementia in the Washington Heights Inwood Columbia Aging Project (WHICAP-PERIoD)

NINDS R01 NS067443-01A1: RCT: Effect of Novel Intervention to Improve Stroke Symptom Recognition, as Co-Investigator

NIH Grants

  • STATEWIDE DISSEMINATION OF A SCHOOL-BASED PUBLIC STROKE EDUCATION INTERVENTION (Federal Gov)

    Mar 1 2016 - Feb 28 2021

    DOMINANTLY INHERITED ALZHEIMER (Federal Gov)

    Jul 1 2014 - Dec 31 2019

    CENTER OF EXCELLENCE IN ALZHEIMER DISEASE (NYS) (NY State Gov)

    Jul 1 2016 - Feb 28 2017

    PERIODONTITIS EXPOSURE AND RISK OF INCIDENT DEMENTIA (Federal Gov)

    Sep 17 2013 - Aug 31 2016

    CENTER FOR STROKE DISAPARITIES SOLUTION, PROJECT III (Federal Gov)

    Sep 30 2012 - Aug 31 2016

    ASSESSING EFFICIENCY OF LEARNING THE NEUROLOGIC EXAM WITH A VISUAL TRACKING DEVICE (Private)

    Jan 1 2012 - Mar 31 2013

    ARTERIOSCLEROSIS AND ALZHEIMER"S IN A MULTIETHNIC GROUP OF A UTOPSY BRAINS (Private)

    Sep 1 2008 - Jun 30 2011

    HARLEM HOSPITAL AFFILIATION CONTRACT - GENERAL (NY Local Gov)

    Jul 1 2005 - Jun 30 2008

Publications

Original Peer Reviewed Articles:

Williams O, Noble JM. "Hip-Hop" Stroke: A Stroke Educational Program for Elementary School Children Living in a High-Risk Community. Stroke. 2008; 39:2809-2816

Noble JM, Borrell LN, Papapanou PN, Elkind M, Scarmeas N, Wright C. Association of the Periodontitis Pathogen Porphyromonas gingivalis with Poor Memory: Analysis of the Third National Health and Nutrition Examination Survey (NHANES-III). J Neurol Neurosurg Psychiatr 2009 Nov;80(11):1206-11

Noble JM, Manly JJ, Schupf N, Tang MX, Mayeux R, Luchsinger JA. Association of C-reactive protein with cognitive impairment. Arch Neurol. 2010 Jan;67(1):87-92.

Cheng D, Noble JM, Tang MX, Schupf N, Mayeux R, Luchsinger, JA. Type 2 Diabetes and Late Onset Alzheimer’s Disease. Dement Geriatr Cogn Disord 2011;31:424–430

Noble JM, Manly JJ, Schupf N, Tang M-X, Luchsinger JA. Type 2 diabetes and ethnic disparities in cognitive impairment. Ethnicity and Disease 2012; 1: 38-44.

Williams O, DeSorbo A, Noble JM, Gerin W. Child-Mediated Stroke Communication: Findings from Hip Hop Stroke. Stroke 2012 Jan;43(1):163-9.

Williams OA, DeSorbo AL, Noble JM, Shaffer M, Gerin W. Long-term learning of stroke knowledge among children in a high-risk community. Neurology 2012 Aug 21;79(8):802-6

DeSorbo A, Noble J, Shaffer M, Gerin W, Williams O. The Use of an Audience Response System in an Elementary School-Based Health Education Program. Health Education and Behavior.  2013 Oct;40(5):531-5.

Williams O, Hecht MF, Desorbo AL, Huq S, Noble JM. Effect of a Novel Video Game on Stroke Knowledge of 9- to 10-Year-Old, Low-Income Children. Stroke. 2014 Jan 30 [epub ahead of print]

Noble JM, Hedmann MG, Williams O. Improving dementia health literacy using the FLOW mnemonic: pilot findings from the Old S.C.H.O.O.L. Hip Hop Program. Health Education & Behavior (in press)

Case Reports:

*Noble JM, Canoll P, Honig LS. Brain Tumor-Associated Dementia. Sci. Aging Knowl. Environ. 2005 Aug 24; 2005(34):dn2

*Noble JM, Anderson CT, Etienne M, Williams O, Adams DJ. Sarcoid meningitis with fulminant delirium and markedly abnormal cerebrospinal fluid. Arch Neurol 2007 Jan;64(1):129-31

Sommerville RB, Noble JM, Vonsattel JP, DeLaPaz R, Wright CB.  Eosinophilic Vasculitis in an Isolated CNS Distribution. J Neurol Neurosurg Psychiatry.2007;78:85-88.

*Noble JM, Mandel A, Patterson MC. Scurvy and Rickets Masked by Chronic Neurologic Illness: Revisiting “Psychologic Malnutrition.” Pediatrics. 2007 March;119(3):e783-90.

*Etienne M, Noble JM. Multiple parenchymal tuberculomas without tuberculous meningitis. Arch Neurol. 2007;64:1045-1047.

Reviews:

Luchsinger JA, Noble JM, Scarmeas N. Diet and Alzheimer's Disease. Curr Neurol Neurosci Rep. 2007 Sep;7(5):366-372.

*Noble JM, Patterson MC. “Vitamin C Deficiency,” invited review for BMJ Point of Care (BMJ Publishing Group), original publication 2008; updated 2009-12.

*Noble JM, Scarmeas N. Application of PET Imaging to Diagnosis of Alzheimer’s Disease and Mild Cognitive Impairment. Int Rev Neurobiol 2009;84C:133-149

Noble J, Scarmeas N, Papapanou PN. Poor oral health as a chronic, potentially modifiable dementia risk factor: review of the literature. Curr Neurol Neurosci Rep. 2013 Oct;13(10):384.

Noble J, Hesdorffer D. Sport-Related Concussions: A Review of Epidemiology, Challenges in Diagnosis, and Potential Risk Factors. Neuropscyhol Rev 2013 Dec;23(4):273-84.

*Noble JM, Weimer LH. Chronic complications of Alcohol Abuse. AAN Continuum. 2014 June (in preparation)

Book Chapters:

*Noble JM, Scarmeas N. “Cognitive impairment.” Improving Oral Health for the Elderly: An Interdisciplinary Approach. Eds. Ira B. Lamster, DDS, MMSc, and Mary E. Northridge, PhD, MPH. Springer US Books 2008.

*Noble JM, Scarmeas N. “Frontotemporal dementia” Merritt’s Neurology, 12th ed. Eds: Lewis P. Rowland and Timothy A. Pedley. LWW 2010.

Sevigny J, Frontera J, Noble JM. Viral Infections of the Nervous System, Current Diagnosis and Treatment in Neurology, 2nd ed. Ed: John CM Brust, Lange 2012.

Rippon G and Noble JM. “Parkinson Disease Dementia and Dementia with Lewy Bodies.” Current Diagnosis and Treatment in Neurology, 2nd ed. Ed: John CM Brust, Lange 2012.

Published Correspondence:

Noble JM, Hauser WA. [Correspondence to] Effects of rivastigmine on cognitive function in patients with traumatic brain injury. Neurology 2007 May 15;68(20):1749

Dhamoon M, Noble JM. [Correspondence to] Intranasal insulin improves cognition and modulates beta-amyloid in early AD.  Neurology. 2009 Jan 20;72(3):292-294.

Published Abstracts:

Williams O, Noble JM, Brust JCM. Recombinant Tissue Plasminogen Activator (rtPA) for Acute Ischemic Stroke among African Americans in Central Harlem. Annals of Neurology, 2005, 58 (S9), p S45

Williams O, Noble JM, Brust JCM. Stroke Associated with Cocaine Abuse: No Longer Just a Problem of the Young. Neurology. March 2006; 66 (Suppl 2): A384.

*Williams O, Noble JM. “Hip-Hop” Stroke Education in Central Harlem Elementary Schools: Pilot Data from a Novel Intervention and Proposed Educational Model for Stroke Awareness Developed by the National Stroke Association. Stroke 2007.38:457-8.

*Noble JM, Scarmeas N, Honig L. Challenges in dementia diagnosis in a multiethnic population. Neurology 2007; 68 Suppl 1:A237

*Noble JM, Manly JJ, Schupf N, Mayeux R, Luchsinger JA. Possible disparate contribution of diabetes to cognitive impairment in elderly minorities. Neuroepidemiology 2007; 28:125.

Williams O, Wowo B, Noble J, Brust J. Insurance Coverage And Ambulance Use During Acute Stroke In A Low Income Inner City Population. Stroke 2008; 39:627.

*Noble J, Borrell LN, Papapanou PN, Elkind M, Scarmeas N, Wright C. Association of the Periodontitis Pathogen Porphyromonas gingivalis with Poor Memory: Analysis of the Third National Health and Nutrition Examination Survey (NHANES-III). Neurology 2008; 70 Suppl 1: A191.

*Noble J, Schupf N, Luchsinger J. Relation of high sensitivity C-reactive protein with plasma amyloid beta. Neurology 2009; 72 Suppl 3: A53

Noble JM, Manly JJ, Schupf N, Tang MX, Mayeux R, Luchsinger JA. “Relation of C-reactive protein to cognitive impairment.” Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2009; 5(4S): P297

Luchsinger JA, Noble JM, Tang MX, Mayeux R. “Hyperinsulinemia, defined as low adiponectin or type 2 diabetes in the elderly, is related with higher late-onset Alzheimer's disease risk” Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2009; 5(4S): P386

Williams O, DeSorbo A, Noble JM. Lifetime Acquired Stroke Knowledge in a High Risk Community: Parents Versus Children. Annals of Neurology, 2010, 68 (S14), p S11

Williams OA, Gerin W, DeSorbo AL, Noble JM. “A Novel Interventional Strategy to Improve Stroke Awareness: The Hip Hop Stroke Project.” Psychosomatic Medicine 2011; 73 (3) A100.

Williams O, DeSorbo A, Noble J. Hip Hop Stroke: Long-Term Retention of Stroke Knowledge Among Sixth Graders Living in a Low-Income Neighborhood. Stroke 2012 43: A2476

Williams O, DeSorbo A, Noble J. Hip Hop Stroke: The Standalone Effect of Musical Cartoons on Stroke Knowledge of Fourth Grade Children Living in a Low-Income Neighborhood. Stroke 2012 43: A2476

Noble J, Scarmeas N, Celentia R, Elkind M, Wright C, Schupf N, Papapanou N. Serum Antibodies to Periodontal Pathogens are associated with Incident Alzheimer Disease. Alzheimer’s & Dementia 2012, 8(4), P498

Noble J, Kang M-S, Honig L. Arteriosclerosis and Alzheimer's disease: A case-control pathologic study. Alzheimer’s & Dementia 2012, 8(4), P298

Collins-Praino L, Scarmeas N, Manly J, Schupf N, Noble J, Provenzano F, Griffith E, DeCarli C, Mayeux R, Luchsinger J, Brickman A. White Matter Hyperintensities May Mediate the Relationship Between Inflammation and Cognition in an Elderly Cohort. Alzheimer’s & Dementia 2012, 8(4), P523

Shams T, Brickman AM, Gossett J, Levine W, Noble JM. Subtle Post-Concussion Cognitive Impairment Is Under-Recognized, and yet Identifiable: Findings from the Concussion in Columbia University Sports Student (ConCUSS) Study [ABSTRACT]  Ann Neurol Dec 2013: 74(S17); page S37.

For a complete list of publications, please visit PubMed.gov